why is chewing tobacco harmful New study reveals extreme variability of chemicals in smokeless products in India - School of Public Health Chewing tobacco - Wikipedia

Fourth, the reduction in the prevalence of alcohol and tobacco was not uniform across the districts

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Al-Krenawi A, Al-Natsheh N, Al-Habies FA, Abudoush A, Al-Jaafreh S, Alqudah A, et al

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They pooled data from 15 casecontrol studies, which included 10,244 head and neck cancer patients and 15,227 controls

Nicotine, the addictive constituent of tobacco, meets these criteria because a typical withdrawal syndrome occurs after smoking cessation, tolerance to its use develops, and most importantly, use persists after developing symptoms attributable to the substance and in the face of its known harm